SenesTech, Inc.?Humane Animal Population Management
SenesTech
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5/31 » Possum: pest experts
5/29 » Accidental Discovery
5/27 » Feed Millions
5/20 » World Hunger
4/13 » Kangaroos
1/29 » Athena Award
1/29 » Honors Science Geek
11/18 » Incubator to Hatch
11/10 » AUS Registration
10/24 » Field Trials
2009 Publications

Reproductive Toxicology
AMH in follicle-depleted mice
Sukhdeep K. Sahambi, Ph.D.
2008

JAVMA News
Getting beyond surgical contraception
R. Scott Nolen
January 15, 2007

Comparative Medicine
Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause
Patricia B. Hoyer, Ph.D.
December, 2005

Arteriosclerosis, Thrombosis, and Vascular Biology
Atherosclerotic Lesion Development in a Novel Ovary-Intact Mouse Model of Perimenopause
Loretta P. Mayer, Ph.D.
September, 2005

Toxicology and Applied Pharmacology
Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss
Patricia B. Hoyer, Ph.D.
July, 2004

Biology of Reproduction
The Follicle-Deplete Mouse Ovary Produces Androgen
Loretta P. Mayer, Ph.D.
March, 2004

Toxicological Sciences
Expression and Activity of Cytochromes P450 2E1, 2A, and 2B in the Mouse Ovary: The Effect of 4-Vinylcyclohexene and Its Diepoxide Metabolite
Cheryl A. Dyer, Ph.D.
2003

 

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Enterprise: SenesTech, Inc. (SenesTech) is a platform biotechnology company specializing in reproductive physiology. It's mission is to complete the development of non-surgical reproduction management technology that could profoundly change the world via wildlife  and companion animal population control. We are currently applying our revolutionary technology to the control of the Southeast Asian Rice Rat in order to increase rice production. We believe that with the application of our product, ContraPest™, we will be able to feed at least an additional 380 million people annually within three years. SenesTech is developing strategic partnerships with international industry partners, non-profit institutions, and universities to accelerate the translation of its platform technology into marketable products within 15 months.

Technology: SenesTech believes its technology is the first of its kind inthe world. We are conducting cutting-edge research in mammalian female senescence and developing animal research models, advancing efforts in wildlife population management, and developing companion animal chemical spay technology. The technology is based on the development of species-specific protocols to chemically accelerate the natural depletion of the non-regenerating pool of primordial and primary follicles in the mammalian ovary, resulting in ovarian failure and sterility. The protocol has been refined and optimized to achieve follicle depletion without causing systemic toxicity or adverse side effects and is environmentally neutral, so it will not affect the food chain.

Company Background: SenesTech was founded in 2002 in Flagstaff, Arizona and is based on technology licensed from the University of Arizona. It has recently entered into a strategic alliance with the government of Australia to service the needs of Australia, New Zealand, and Southeast Asia in rodent population management. Domestic and International patents are pending.

Management: Everett P. Hale is SenesTech’s Chief Executive Officer. Mr. Hale has extensive experience in management, operations and taking start-up companies to the IPO stage. Three scientists have been involved in the research that forms the basis of SenesTech’s platform technology. Loretta P. Mayer, Ph.D. is the Chief Scientific Officer and serves as Chairman of the Board. Cheryl A. Dyer, Ph.D. is the lead scientist for development of commercial delivery of the technology and serves as President. Timothy L. Vail, Ph.D. is the Vice President of Manufacturing and Regulation. Roger Bollard, CPA is the Chief Financial Officer.

Market: Initial market analyses indicate a primary market in rodent management within agriculture, with a secondary market in companion animal chemical spay. SenesTech’s rodent fertility control product ContraPest™ will replace the use of poisons in a world market that can suffer up to 33% crop losses due to rodent infestations. Annual sales are projected to supplant current poison products within three years with annual revenue in excess of $1 billion. A humane method for population management of wild animals such as deer, coyotes, foxes, raccoons, horses, buffalo, elk as well as feral dogs and cats represent potential follow-on market segments. At an international meeting of scientists in Washington DC in November 2006 ChemSpay™ was determined to be the only irreversible product in development that can adequately address the dog and cat overpopulation problems.

Products and Services: ContraPest™, which will be delivered via oral baiting, will be registered first in Australia and marketed to the Southeast Asian rice producing countries to address the immediate need of increased rice production to help alleviate world-wide famine. The technology will then be expanded to other species and subsequently to address the overpopulation of feral dogs and cats, as well as, companion animals worldwide as ChemSpay™.

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