SenesTech, Inc.

Loretta Mayer, Ph.D. | Everett Hale, MBA | Cheryl A. Dyer, Ph.D. | Roger T. Bollard, CPA | Timothy Vail, Ph.D.
Histology | Imaging
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Publications

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SenesTech in the News

NBC Channel 2 - Flagstaff, Arizona
Local scientists make a worldwide impact
July 2008

Video from the SenesTech display at BIO 2008
June 2008

Intellectual Property Office of New Zealand Patent Search
New Zealand patent for "Animal model for perimenopause and menopause and methods of inducing ovarian failure".
June 27, 2008

Flinn Foundation
AMH in follicle-depleted mice.
June 18, 2008

Flinn Foundation
Flagstaff firm inks deal with Australia for rodent control test
June 18, 2008

Australian Broadcast Company
Recent Australian Broadcast Company production on rice shortages that SenesTech, Inc. products are designed to address.
June 15, 2008

Arizona Daily Sun
City of Flagstaff's economic vitality report
April 23, 2008

Arizona Daily Sun
Rats facing NAU spay chemical
April 23, 2008

Flinn Foundation
State bioindustry association reorganizes, names new board
March 20, 2008

Arizona Republic
BioIndustry Association to showcase 15 firms
March 19, 2008

Horizons Magazine, Northern Arizona University
Of Mice and Women
Spring 2008

ACC&D
ACC&D Agenda for Advancement
November 2006

ACC&D
Beyond Spaying and Neutering
Fall 2006

Animal Guardian
Just What the Doctor Ordered
November 2006

Feral Flyer, IACRC
“Dogpeople” Conference in Darwin a great success: fertility control in the spotlight
2006

www.DogPeople.com.au
The end of surgical spaying?
2006

Dog People Conference, July 16-21, 2006, Darwin Australia.
Press Release: The demise of surgical spaying?

Editorial: Arteriosclerosis, Thrombosis, and Vascular Biology
A Mouse Model of the Perimenopausal Transition: Importance for Cardiovascular Research.
J. Koudy Williams, D.V.M.
September, 2005

The Jackson Laboratory
Women’s Health Resource Manual
Summer, 2005

Of Mice and Money
BioBusiness
July, 2005

Northern Arizona University
Researcher speeds the way to menopause
July, 2005

TechConnect Magazine
Ten Biotech Companies to Watch
Spring 2005

JAX NOTES
The Jackson Laboratory
A New Hormonally Relevant Model for Human Menopause
Winter 2005

JAX NOTES
The Jackson Laboratory
A New Mouse Model for Ovarian Follicle Loss in Post-menopausal Women
Summer 2004

Arizona Daily Wildcat
Guinea Pigs needed for human health
February 9, 2004

Arizona Daily Wildcat
Mouse with a mission
February 6, 2004

Arizona Daily Wildcat
Mice face menopause for sake of womankind
February 3, 2004

JAX NOTES
The Jackson Laboratory
Menopause
January, 2004

Report on Research
University of Arizona
Of Mice and Women
January, 2004

Arizona Daily Sun
Many healthy returns
August 24, 2003

Arizona Daily Sun
Local tech companies on FAST track
August 17, 2003

Phoenix Business Journal
Companies given state grants
July 30, 2003

Arizona Governor’s Office
Press Release
Innovative High Tech Firms Receive Governor’s AZ Fast Grant Awards
July 29, 2003

Scientific Journals

Reproductive Toxicology
AMH in follicle-depleted mice.
Sukhdeep K. Sahambi, Ph.D.
2008

JAVMA News
Getting beyond surgical contraception
R. Scott Nolen
January 15, 2007

Comparative Medicine
Characterization of cyclicity and hormonal profile with impending ovarian failure in a novel chemical-induced mouse model of perimenopause
Patricia B. Hoyer, Ph.D.
December, 2005

Arteriosclerosis, Thrombosis, and Vascular Biology
Atherosclerotic Lesion Development in a Novel Ovary-Intact Mouse Model of Perimenopause
Loretta P. Mayer, Ph.D.
September, 2005

Toxicology and Applied Pharmacology
Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss
Patricia B. Hoyer, Ph.D.
July, 2004

Biology of Reproduction
The Follicle-Deplete Mouse Ovary Produces Androgen
Loretta P. Mayer, Ph.D.
March, 2004

Toxicological Sciences
Expression and Activity of Cytochromes P450 2E1, 2A, and 2B in the Mouse Ovary: The Effect of 4-Vinylcyclohexene and Its Diepoxide Metabolite
Cheryl A. Dyer, Ph.D.
2003

Environmental Health Perspectives
Exposure to 4-tert-Octylphenol Accelerates Sexual Differentiation and Disrupts Expression of Steroidogenic Factor 1 in Developing Bullfrogs
Loretta P. Mayer, Ph.D.
April, 2003

Toxicological Sciences
Expression and Activity of Microsomal Epoxide Hydrolase in FolliclesIsolated from Mouse Ovaries
Cheryl A. Dyer, Ph.D.
2002

Biology of Reproduction
Activation of Mitogen-Activated Protein Kinases and AP-1 Transcription Factor in Ovotoxicity Induced by 4-Vinylcyclohexene Diepoxide in Rats
Patricia B. Hoyer, Ph.D.
September 2002

General and Comparative Endocrinology
Sexually dimorphic expression of steroidogenic factor 1 (SF-1)in developing gonads of the American bullfrog, Rana catesbeiana
Loretta P. Mayer, Ph.D.
2002

Toxicology and Applied Pharmacology
Characterization of a Rat in Vitro Ovarian Culture System to Study the Ovarian Toxicant 4-Vinylcyclohexene Diepoxide
Patricia B. Hoyer, Ph.D.
August, 2002

Biology of Reproduction
Hepatic Lipase Deficiency Attenuates Mouse Ovarian Progesterone Production Leading to Decreased Ovulation and Reduced Litter Size
Cheryl A. Dyer, Ph.D.
2002

Reproductive Toxicology
Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide
Loretta P. Mayer, Ph.D.
2002

Endocrinology
17β-Estradiol Affords Protection against 4-Vinylcyclohexene Diepoxide-Induced Ovarian Follicle Loss in Fischer-344 Rats
Patricia B. Hoyer, Ph.D.
March, 2002

Toxicological Sciences
Methoxychlor May Cause Ovarian Follicular Artesia and Proliferation of the Ovarian Epithelium in the Mouse
Loretta P. Mayer, Ph.D.
2002

Biology of Reproduction
Apolipoprotein E Is a Putative Autocrine Regulator of the Rat OvarianTheca Cell Compartment
Cheryl A. Dyer, Ph.D.
2001

Biology of Reproduction
Apoptosis Induced in Rats by 4-Vinylcyclohexene Diepoxide Is Associated with Activation of the Caspase Cascades
Patricia B. Hoyer, Ph.D.
July, 2001

Biology of Reproduction
Apolipoprotein E Is a Putative Autocrine Regulator of the Rat Ovarian Theca Cell Compartment
Loretta P. Mayer, Ph.D.
2001

Biology of Reproduction
Expression and Redistribution of Cellular Bad, Bax, and Bcl-xL Protein Is Associated with VCD-Induced Ovotoxicity in Rats
Patricia B. Hoyer, Ph.D.
November, 2001

Reproductive Toxicology
Early Effects of Ovototoxicity Induced by 4-Vinylcyclohexene Diepoxide in Rats and Mice
Patricia B. Hoyer, Ph.D.
January, 1999

Biology of Reproduction
Apolipoprotein E Peptide Stimulation of Rat Ovarian Theca Cell Androgen Synthesis is Mediated by Members of the Low Density Lipoprotein Receptor Superfamily
Cheryl A. Dyer, Ph.D.
1999

Toxicology and Applied Pharmacology
A Single Dose of the Ovotoxicant 4-Vinylcyclohexene Diepoxide Is Protective in Rat Primary Ovarian Follicles
Patricia B. Hoyer, Ph.D.
April, 1999

Journal of Lipid Research
An apolipoprotein E synthetic peptide selectively modulates the transcription of the gene for rat ovarian theca and interstitial cell P450 17α-hydroxylase, C17–20 lyase
Cheryl A. Dyer, Ph.D.
1998

Toxicology and Applied Pharmacology
Involvement of Apoptosis in 4-Vinylcyclohexene Diepoxide-Induced Ovotoxicity in Rats
Patricia B. Hoyer, Ph.D.

March, 1996

Toxicology and Applied Pharmacology
Enhanced Expression of bax in Small Preantral Follicles during 4-Vinylcyclohexene Diepoxide-Induced Ovotoxicity in the Rat
Patricia B. Hoyer, Ph.D.
May, 1996

Journal of Lipid Research
Structural features of synthetic peptides of apolipoprotein E that bind the LDL receptor
Cheryl A. Dyer, Ph.D.
1995

Reproductive Toxicology
Long-Term Ovarian And Gonadotropin Changes In Mice Exposed To 4-Vinylcyclohexene
Patricia B. Hoyer, Ph.D.
July, 1994

Reproductive Toxicology
Destruction Of Preantral Follicles In Adult Rats By 4-Vinyl-1-Cyclohexene Diepoxide
Patricia B. Hoyer, Ph.D.
November, 1994

Journal of Lipid Research
THP-1 cells form foam cells in response to coculture with lipoproteins but not platelets
Cheryl A. Dyer, Ph.D.
1991

The Journal Of Biological Chemistry
A Synthetic Peptide Mimic of Plasma Apolipoprotein E That Binds the LDL Receptor
Cheryl A. Dyer, Ph.D.
December, 1991

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